Genetic diversity of circumsporozoite protein in Plasmodium knowlesi isolates

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Diagnostic and prognostic worth of MCM3 and its interacting proteins in hepatocellular carcinoma

Aberrant DNA replication is likely one of the driving forces behind oncogenesis. Moreover, minichromosome upkeep advanced part 3 (MCM3) serves a necessary position in DNA replication.

Subsequently, within the current examine, the diagnostic and prognostic worth of MCM3 and its interacting proteins in hepatocellular carcinoma (HCC) have been investigated. By using The Most cancers Genome Atlas (TCGA) database, world MCM3 mRNA ranges have been assessed in HCC and regular liver tissues.

Its results have been additional analyzed by reverse transcription-quantitative PCR (RT-qPCR), western blotting and immunohistochemistry in 78 paired HCC and adjoining tissues. Purposeful and pathway enrichment analyses have been carried out utilizing the Search Instrument for the Retrieval of Interacting Genes database. The expression ranges of proteins that work together with MCM3 have been additionally analyzed utilizing the TCGA database and RT-qPCR.

Lastly, algorithms combining receiver working attribute (ROC) curves have been constructed utilizing binary logistic regression utilizing the TCGA outcomes. Elevated MCM3 mRNA expression with excessive α-fetoprotein ranges and superior Edmondson-Steiner grade have been discovered to be attribute of HCC. Survival evaluation revealed that top MCM3 expression was related to poor outcomes in sufferers with HCC.

As well as, MCM3 protein expression was related to elevated tumor invasion in HCC tissues. MCM3 and its interacting proteins have been discovered to be primarily concerned in DNA replication, cell cycle and various binding processes. Algorithms combining ROCs of MCM3 and its interacting proteins have been discovered to have improved HCC prognosis capability in contrast with MCM3 and different particular person diagnostic markers. In conclusion, MCM3 seems to be a promising diagnostic biomarker for HCC. Moreover, the current examine gives a foundation for the multi-gene prognosis of HCC utilizing MCM3.

Genetic range of circumsporozoite protein in Plasmodium knowlesi isolates from Malaysian Borneo and Peninsular Malaysia

Background: Understanding the genetic range of candidate genes for malaria vaccines comparable to circumsporozoite protein (csp) might improve the event of vaccines for treating Plasmodium knowlesi. Therefore, the intention of this examine is to research the genetic range of non-repeat areas of csp in P. knowlesi from Malaysian Borneo and Peninsular Malaysia.

Strategies: A complete of 46 csp genes have been subjected to polymerase chain response amplification. The genes have been obtained from P. knowlesi isolates collected from completely different divisions of Sabah, Malaysian Borneo, and Peninsular Malaysia. The focused gene fragments have been cloned right into a business vector and sequenced, and a phylogenetic tree was constructed whereas incorporating 168 csp sequences retrieved from the GenBank database.

The genetic range and pure evolution of the csp sequences have been analysed utilizing MEGA6 and DnaSP ver. 5.10.01. A genealogical community of the csp haplotypes was generated utilizing NETWORK ver. 4.6.1.3.

Outcomes: The phylogenetic evaluation revealed indistinguishable clusters of P. knowlesi isolates throughout completely different geographic areas, together with Malaysian Borneo and Peninsular Malaysia. Nucleotide evaluation confirmed that the csp non-repeat areas of zoonotic P. knowlesi isolates obtained on this examine underwent purifying choice with inhabitants enlargement, which was supported by in depth haplotype sharing noticed between people and macaques. Novel variations have been noticed within the C-terminal non-repeat area of csp.

Conclusions: The csp non-repeat areas are comparatively conserved and there’s no distinct cluster of P. knowlesi isolates from Malaysian Borneo and Peninsular Malaysia. Distinctive variation knowledge obtained within the C-terminal non-repeat area of csp may very well be useful for the design and growth of vaccines to deal with P.

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Chicken Interleukin 8 (IL8) ELISA Kit

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Interleukin 8 (IL8) Monoclonal Antibody (Horse)

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  • Sequence of the immunogen: Ala23~Pro101
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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Chicken)

4-MAA080Ga22
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  • Sequence of the immunogen: Ala17~Leu103
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human)

4-MAA080Hu22
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  • Sequence of the immunogen: Ser28~Ser99
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human)

4-MAA080Hu24
  • EUR 221.00
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  • Sequence of the immunogen: Ser28~Ser99
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

4-MAA080Po22
  • EUR 249.00
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  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

4-MAA080Po24
  • EUR 249.00
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  • Sequence of the immunogen: Ala26~Gln103
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

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  • EUR 249.00
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  • Sequence of the immunogen: Ala26~Gln103
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit)

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  • EUR 251.00
  • EUR 2589.00
  • EUR 643.00
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  • Sequence of the immunogen: Ala23~Ser101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8)

Guinea pig Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Gu-48T 48T
EUR 388
  • Should the Guinea pig Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
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EUR 496
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Guinea pig Interleukin 8 (IL8) ELISA Kit

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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

20-abx131839
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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

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  • EUR 411.00
  • EUR 133.00
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Interleukin 8 (IL8) Antibody

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Interleukin 8 (IL8) Antibody

20-abx100964
  • EUR 300.00
  • EUR 704.00
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  • 100 ug
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Interleukin 8 (IL8) Antibody

20-abx100965
  • EUR 398.00
  • EUR 133.00
  • EUR 1066.00
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Interleukin 8 (IL8) Antibody

20-abx100966
  • EUR 314.00
  • EUR 773.00
  • EUR 411.00
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  • EUR 258.00
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Interleukin 8 (IL8) Antibody

20-abx100967
  • EUR 411.00
  • EUR 133.00
  • EUR 1163.00
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  • EUR 314.00
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Interleukin 8 (IL8) Antibody

20-abx100969
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
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Interleukin 8 (IL8) Antibody

20-abx100970
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
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  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx100971
  • EUR 453.00
  • EUR 133.00
  • EUR 1316.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
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  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100972
  • EUR 467.00
  • EUR 133.00
  • EUR 1372.00
  • EUR 648.00
  • EUR 356.00
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Interleukin 8 (IL8) Antibody

20-abx009111
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  • EUR 189.00
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Interleukin 8 (IL8) Antibody

abx020956-05mg 0.5 mg
EUR 1080
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Interleukin 8 (IL8) Antibody

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EUR 342
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Interleukin 8 (IL8) Antibody

20-abx173191
  • EUR 356.00
  • EUR 913.00
  • EUR 467.00
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Interleukin 8 (IL8) Antibody

20-abx177199
  • EUR 356.00
  • EUR 133.00
  • EUR 1038.00
  • EUR 523.00
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  • 100 ug
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  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx177201
  • EUR 1191.00
  • EUR 578.00
  • 1 mg
  • 200 ug
  • Please enquire.

Interleukin 8 (IL8) Antibody

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EUR 439
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Interleukin 8 (IL8) Antibody

20-abx270103
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
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Interleukin 8 (IL8) Antibody

20-abx270152
  • EUR 467.00
  • EUR 537.00
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Interleukin 8 (IL8) Antibody

20-abx270200
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
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  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx270201
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog)

4-MAA080Ca22
  • EUR 221.00
  • EUR 2114.00
  • EUR 535.00
  • EUR 274.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Horse), APC

4-MAA080Eq21-APC
  • EUR 382.00
  • EUR 3797.00
  • EUR 1043.00
  • EUR 492.00
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), Biotinylated

4-MAA080Eq21-Biotin
  • EUR 338.00
  • EUR 2842.00
  • EUR 823.00
  • EUR 419.00
  • EUR 230.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), Cy3

4-MAA080Eq21-Cy3
  • EUR 468.00
  • EUR 5021.00
  • EUR 1349.00
  • EUR 614.00
  • EUR 271.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), FITC

4-MAA080Eq21-FITC
  • EUR 325.00
  • EUR 3057.00
  • EUR 854.00
  • EUR 413.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), HRP

4-MAA080Eq21-HRP
  • EUR 348.00
  • EUR 3307.00
  • EUR 920.00
  • EUR 443.00
  • EUR 220.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), PE

4-MAA080Eq21-PE
  • EUR 325.00
  • EUR 3057.00
  • EUR 854.00
  • EUR 413.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), APC

4-MAA080Ga22-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), Biotinylated

4-MAA080Ga22-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), Cy3

4-MAA080Ga22-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), FITC

4-MAA080Ga22-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), HRP

4-MAA080Ga22-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), PE

4-MAA080Ga22-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig)

4-MAA080Gu21
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Met23~Ser101
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig)

4-MAA080Gu24
  • EUR 259.00
  • EUR 2708.00
  • EUR 670.00
  • EUR 328.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Met23~Ser101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human), APC

4-MAA080Hu22-APC
  • EUR 307.00
  • EUR 2735.00
  • EUR 777.00
  • EUR 386.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu22-Biotin
  • EUR 283.00
  • EUR 2064.00
  • EUR 628.00
  • EUR 341.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Cy3

4-MAA080Hu22-Cy3
  • EUR 368.00
  • EUR 3605.00
  • EUR 995.00
  • EUR 473.00
  • EUR 229.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Human), FITC

4-MAA080Hu22-FITC
  • EUR 266.00
  • EUR 2208.00
  • EUR 642.00
  • EUR 328.00
  • EUR 182.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), HRP

4-MAA080Hu22-HRP
  • EUR 283.00
  • EUR 2387.00
  • EUR 690.00
  • EUR 351.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Human), PE

4-MAA080Hu22-PE
  • EUR 266.00
  • EUR 2208.00
  • EUR 642.00
  • EUR 328.00
  • EUR 182.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Human), APC

4-MAA080Hu24-APC
  • EUR 307.00
  • EUR 2735.00
  • EUR 777.00
  • EUR 386.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu24-Biotin
  • EUR 283.00
  • EUR 2064.00
  • EUR 628.00
  • EUR 341.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Cy3

4-MAA080Hu24-Cy3
  • EUR 368.00
  • EUR 3605.00
  • EUR 995.00
  • EUR 473.00
  • EUR 229.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Human), FITC

4-MAA080Hu24-FITC
  • EUR 266.00
  • EUR 2208.00
  • EUR 642.00
  • EUR 328.00
  • EUR 182.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), HRP

4-MAA080Hu24-HRP
  • EUR 283.00
  • EUR 2387.00
  • EUR 690.00
  • EUR 351.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Human), PE

4-MAA080Hu24-PE
  • EUR 266.00
  • EUR 2208.00
  • EUR 642.00
  • EUR 328.00
  • EUR 182.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC

4-MAA080Po22-APC
  • EUR 349.00
  • EUR 3329.00
  • EUR 926.00
  • EUR 445.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po22-Biotin
  • EUR 314.00
  • EUR 2499.00
  • EUR 737.00
  • EUR 384.00
  • EUR 220.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Cy3

4-MAA080Po22-Cy3
  • EUR 423.00
  • EUR 4397.00
  • EUR 1193.00
  • EUR 552.00
  • EUR 253.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), FITC

4-MAA080Po22-FITC
  • EUR 299.00
  • EUR 2683.00
  • EUR 760.00
  • EUR 376.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), HRP

4-MAA080Po22-HRP
  • EUR 319.00
  • EUR 2901.00
  • EUR 819.00
  • EUR 402.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), PE

4-MAA080Po22-PE
  • EUR 299.00
  • EUR 2683.00
  • EUR 760.00
  • EUR 376.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC

4-MAA080Po24-APC
  • EUR 349.00
  • EUR 3329.00
  • EUR 926.00
  • EUR 445.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po24-Biotin
  • EUR 314.00
  • EUR 2499.00
  • EUR 737.00
  • EUR 384.00
  • EUR 220.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

The non-hormonal male contraceptive adjudin exerts its results through MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407

Adjudin, 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (previously referred to as AF-2364), is a non-hormonal male contraceptive because it successfully induces reversible male infertility with out perturbing the serum concentrations of FSH, testosterone and inhibin B.

Adjudin was proven to exert its results preferentially by perturbing the testis-specific actin-rich adherens junction (AJ) on the Sertoli-spermatid interface often called apical ectoplasmic specialization (apical ES), thereby successfully induce spermatid exfoliation. Adjudin didn’t perturb germ cell growth nor germ cell operate.

Additionally, it had no results on Sertoli cell-cell AJ referred to as basal ES – which along with tight junction (TJ) represent the blood-testis barrier (BTB) – except an acute dose of adjudin at was used.

Adjudin additionally didn’t perturb the inhabitants of spermatogonial stem cells nor Sertoli cells within the testis. Nonetheless, the downstream signaling protein(s) utilized by adjudin to induce transient male infertility stays unexplored.

Herein, utilizing grownup rats handled with adjudin and monitored modifications within the phenotypes throughout the seminiferous epithelium between 6 and 96 h in parallel with the steady-state protein ranges of an array of signaling and cytoskeletal regulatory proteins, just lately proven to be concerned in apical ES, basal ES and BTB operate.

It was proven that adjudin exerts its contraceptive results by modifications in microtubule related proteins (MAPs) and signaling proteins mTORC1/rpS6 and p-FAK-Y407. These findings are essential to check adjudin-mediated male infertility but in addition the biology of spermatogenesis.

Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer’s illness

  • Regulation of actin cytoskeleton dynamics in dendritic spines is essential for studying and reminiscence formation. Therefore, defects within the actin cytoskeleton pathways are a organic trait of a number of mind ailments, together with Alzheimer’s illness.
  • Right here, we describe a novel synaptic mechanism ruled by the cyclase-associated protein 2, which is required for structural plasticity phenomena and fully disrupted in Alzheimer’s illness.
  • We report that the formation of cyclase-associated protein 2 dimers by its Cys32is essential for cyclase-associated protein 2 binding to cofilin and for actin turnover.
  • The Cys32-dependent cyclase-associated protein 2 homodimerization and affiliation to cofilin are triggered by long-term potentiation and are required for long-term potentiation-induced cofilin translocation into spines, backbone remodelling and the potentiation of synaptic transmission.
  • This mechanism is particularly affected within the hippocampus, however not within the superior frontal gyrus, of each Alzheimer’s illness sufferers and APP/PS1 mice, the place cyclase-associated protein 2 is down-regulated and cyclase-associated protein 2 dimer synaptic ranges are lowered.
  • Notably, cyclase-associated protein 2 ranges within the cerebrospinal fluid are considerably elevated in Alzheimer’s illness sufferers however not in topics affected by frontotemporal dementia.
  • In Alzheimer’s illness hippocampi, cofilin affiliation to cyclase-associated protein 2 dimer/monomer is altered and cofilin is aberrantly localized in spines. Taken collectively, these outcomes present novel insights into structural plasticity mechanisms which are faulty in Alzheimer’s illness.

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