Artemisinin susceptibility in the malaria parasite Plasmodium falciparum

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Artemisinin susceptibility within the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the necessity for mobile therapeutic

Research of the susceptibility of Plasmodium falciparum to the artemisinin household of antimalarial medication present a fancy image of partial resistance (tolerance) related to elevated parasite survival in vitro and in vivo. We current an outline of the genetic loci that, in mutant kind, can independently elicit parasite tolerance.

These encode kelch propeller area protein PfK13, ubiquitin hydrolase UBP-1, actin filament-organising protein Coronin, additionally carrying a propeller area, and the trafficking adaptor subunit AP-2μ. Detailed research of those proteins and the practical foundation of artemisinin tolerance in blood stage parasites are enabling a brand new synthesis of our understanding thus far. To information additional experimental work, we current two main conclusions.

Firstly, we suggest a dual-component mannequin of artemisinin tolerance in P. falciparum comprising suppression of artemisinin activation in early ring-stage by decreasing endocytic haemoglobin seize from host cytosol, coupled with enhancement of mobile therapeutic mechanisms in surviving cells.

Secondly, these two impartial necessities restrict the chance of growth of full artemisinin resistance by P. falciparum, favouring deployment of current medication in new schedules designed to take advantage of these organic limits, thus extending the helpful lifetime of present mixture therapies.

Manufacturing and characterization of a fusion type of hepatitis E virus t ORF2 capsid protein in Escherichia coli

Hepatitis E virus (HEV) is a nonenveloped virus inflicting an rising zoonotic illness posing a extreme menace to the general public well being on the planet, particularly to pregnant ladies. On this examine, a truncated kind (aa 368-606) of the open studying body 2 of the capsid protein (tORF2-HEV), a main structural protein of HEV, was expressed in Escherichia coli. This work characterizes for the primary time, the fused Glutathione-S-Transferase-tagged tORF2 (GST-tORF2) and tORF2-HEV types in E. coli.

The fusion protein was purified by affinity chromatography with a purity larger than 90% and to yield about 27% after thrombin digestion. The purified GST-tORF2 protein was then characterised by western blot, utilizing anti-GST antibodies, and CD spectroscopy. The GST-tORF2 and tORF2-HEV proteins had been proven to be environment friendly to develop an ELISA take a look at to detect anti-HEV IgG in mice sera immunized with a recombinant full size ORF2 protein. Sera confirmed a major improve of the absorbance sign at 450 nm, in plate wells coated with a amount of 0.5, 1 and a pair of µg of proteins.

ELISA plates coated with the purified GST-tORF2 and tORF2-HEV confirmed related response when in comparison with the HEV ELISA the place whole insect cell lysate, contaminated with the recombinant baculovirus expressing full ORF2, was used as optimistic management.

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Interleukin 8 (IL8) Monoclonal Antibody

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with PE.

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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig)

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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human), FITC

4-MAA080Hu22-FITC
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), FITC

4-MAA080Hu24-FITC
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), APC

4-MAA080Rb22-APC
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), Cy3

4-MAA080Rb22-Cy3
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), HRP

4-MAA080Rb22-HRP
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), APC

4-MAA080Ga22-APC
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), Cy3

4-MAA080Ga22-Cy3
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), HRP

4-MAA080Ga22-HRP
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), FITC

4-MAA080Rb22-FITC
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), FITC

4-MAA080Ga22-FITC
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey)

4-MAA080Si21
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey)

4-MAA080Si22
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po22-Biotin
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  • 20ul
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po24-Biotin
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po26-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), PE

4-MAA080Ca22-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), APC

4-MAA080Ca22-APC
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), Cy3

4-MAA080Ca22-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), HRP

4-MAA080Ca22-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), PE

4-MAA080Gu21-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), PE

4-MAA080Gu24-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po22-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po24-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po26-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), Biotinylated

4-MAA080Eq21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu22-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu24-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

LAA080Rb42 270 ul
EUR 507

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), FITC

4-MAA080Ca22-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC

4-MAA080Gu21-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Cy3

4-MAA080Gu21-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), HRP

4-MAA080Gu21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC

4-MAA080Gu24-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Cy3

4-MAA080Gu24-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), HRP

4-MAA080Gu24-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), Biotinylated

4-MAA080Rb22-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), APC-Cy7

4-MAA080Eq21-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), FITC

4-MAA080Gu21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), FITC

4-MAA080Gu24-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Human), APC-Cy7

4-MAA080Hu22-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Human), APC-Cy7

4-MAA080Hu24-APC-Cy7
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), PE

4-MAA080Si21-PE
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), PE

4-MAA080Si22-PE
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), Biotinylated

4-MAA080Ga22-Biotin
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with Biotin.

FITC-Linked Monoclonal Antibody to Interleukin 8 (IL8)

LAA080Hu82 160 ul
EUR 262

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), APC-Cy7

4-MAA080Rb22-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), APC

4-MAA080Si21-APC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), Cy3

4-MAA080Si21-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), HRP

4-MAA080Si21-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), APC

4-MAA080Si22-APC
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), Cy3

4-MAA080Si22-Cy3
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), HRP

4-MAA080Si22-HRP
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), APC-Cy7

4-MAA080Ga22-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), FITC

4-MAA080Si21-FITC
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), FITC

4-MAA080Si22-FITC
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with FITC.

Biotin-Linked Monoclonal Antibody to Interleukin 8 (IL8)

LAA080Po76 184 ul
EUR 274

Biotin-Linked Monoclonal Antibody to Interleukin 8 (IL8)

LAA080Rb72 209 ul
EUR 279

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), Biotinylated

4-MAA080Ca22-Biotin
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with Biotin.

Mouse Anti Sheep Interleukin-8 Monoclonal Antibody

CABT-48526MS 0.25 mg
EUR 1070.4

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), APC-Cy7

4-MAA080Ca22-APC-Cy7
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Biotinylated

4-MAA080Gu21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Biotinylated

4-MAA080Gu24-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC-Cy7

4-MAA080Gu21-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC-Cy7

4-MAA080Gu24-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), Biotinylated

4-MAA080Si21-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), Biotinylated

4-MAA080Si22-Biotin
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), APC-Cy7

4-MAA080Si21-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey), APC-Cy7

4-MAA080Si22-APC-Cy7
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  • 100ul
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Mouse Anti Human Interleukin-8 Monoclonal Antibody,FITC

CABT-48525MH 100 TEST
EUR 982.8

Interleukin 6 (IL6) Mouse anti-Human Monoclonal Antibody

GWB-E78C44 0.05 ml Ask for price

Mouse Monoclonal Anti-Human Interleukin-8 IgG

AB-11110 100 ug
EUR 416.4

Interleukin 10 (IL10) Monoclonal Antibody (Mouse)

4-MAA056Mu21
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Description: A Rat monoclonal antibody against Mouse Interleukin 10 (IL10)

Interleukin 17 (IL17) Monoclonal Antibody (Mouse)

4-MAA063Mu22
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Description: A Rat monoclonal antibody against Mouse Interleukin 17 (IL17)

Interleukin 34 (IL34) Monoclonal Antibody (Mouse)

4-MAC007Mu21
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Description: A Rat monoclonal antibody against Mouse Interleukin 34 (IL34)

Interleukin 2 (IL2) Monoclonal Antibody (Mouse)

4-MAA073Mu21
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Description: A Rat monoclonal antibody against Mouse Interleukin 2 (IL2)

Interleukin 6 (IL6) Monoclonal Antibody (Mouse)

4-MAA079Mu21
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Description: A Rat monoclonal antibody against Mouse Interleukin 6 (IL6)

Rat Anti Mouse Interleukin-17 Monoclonal Antibody

DMABT-51805RM 0.5 mg
EUR 1132.8

Rat Anti Mouse Interleukin-10 Monoclonal Antibody

CABT-48544RM 0.5 mg
EUR 920.4

Mouse Anti Cat Interleukin-2 Monoclonal Antibody

CABT-48481MC 0.25 mg
EUR 920.4

Acute bodily train will increase PI3K-p110α protein content material within the hypothalamus of overweight mice

The anatomy of the hypothalamus contains many nuclei and a fancy community of neurocircuits. On this context, some hypothalamic nuclei reside nearer to the blood-brain barrier, permitting communication with the peripheral organs by way of some molecules, equivalent to leptin. Leptin is taken into account the principle adipokine for vitality homeostasis management. Moreover, leptin signalling within the hypothalamus can talk with insulin signalling by way of the activation of phosphoinositide 3-kinase (PI3k).

Earlier knowledge recommend that isoforms of PI3k are essential to mediate insulin motion within the hypothalamus. Nonetheless, overweight animals present impairment within the central signalling of those hormones.

Thus, within the present examine, we evaluated the position of acute train within the leptin and insulin pathways within the hypothalamus, in addition to in meals consumption management in overweight mice. Though acute bodily train was not capable of modulate leptin signalling, this protocol suppressed the rise within the suppressor of cytokine signalling 3 (SOCS3) protein ranges.

As well as, acute train elevated the content material of PI3k-p110α protein within the hypothalamus. The exercised animals confirmed a powerful tendency to discount in cumulative meals consumption. For the primary time, our outcomes point out bodily train can improve PI3k-p110α protein content material within the hypothalamus of overweight mice and regulate meals consumption.

Suppression of bromodomain-containing protein Four protects trophoblast cells from oxidative stress damage by enhancing Nrf2 activation

 

Oxidative stress is taken into account a key hallmark of preeclampsia, which causes the dysregulation of trophoblast cells, and it contributes to the pathogenesis of preeclampsia. Rising proof has steered bromodomain-containing protein 4 (BRD4) as a key regulator of oxidative stress in a number of cell varieties. Nonetheless, whether or not BRD4 participates in regulating oxidative stress in trophoblast cells stays undetermined.

The present examine was designed to discover the potential operate of BRD4 within the regulation of oxidative stress in trophoblast cells. Our knowledge revealed that BRD4 expression was elevated in trophoblast cells stimulated with hydrogen peroxide. Publicity to hydrogen peroxide triggered marked decreases within the ranges of proliferation and invasion however promoted apoptosis and the manufacturing of ROS in trophoblast cells. Knockdown of BRD4, or therapy with a BRD4 inhibitor, markedly elevated the degrees of cell proliferation and invasion and decreased apoptosis and ROS manufacturing following the hydrogen peroxide problem.

Additional knowledge indicated that suppression of BRD4 markedly decreased the expression ranges of Keap1, however elevated the nuclear expression of Nrf2 and enhanced Nrf2-mediated transcriptional exercise. BRD4 inhibition-mediated protecting results had been markedly reversed by Keap1 overexpression or Nrf2 inhibition. Total, these outcomes demonstrated that BRD4 inhibition attenuated hydrogen peroxide-induced oxidative stress damage in trophoblast cells by enhancing Nrf2 activation by way of the downregulation of Keap1.

Our examine highlights the potential significance of the BRD4/Keap1/Nrf2 axis within the modulation of the oxidative stress response in trophoblast cells. Focused inhibition of BRD4 could supply new alternatives for the event of progressive therapeutic approaches to deal with preeclampsia.

Protein palmitoylation and its pathophysiological relevance

Protein palmitoylation, by which C16 fatty acid chains are hooked up to cysteine residues by way of a reversible thioester linkage, is without doubt one of the most typical lipid modifications and performs essential roles in regulating protein stability, subcellular localization, membrane trafficking, interactions with effector proteins, enzymatic exercise, and quite a lot of different mobile processes. Furthermore, the distinctive reversibility of palmitoylation permits proteins to be quickly shuttled between organic membranes and cytoplasmic substrates in a course of normally managed by a member of the DHHC household of protein palmitoyl transferases (PATs).

Notably, mutations in PATs are carefully associated to quite a lot of human illnesses, equivalent to most cancers, neurological problems, and immune deficiency situations. Along with PATs, intracellular palmitoylation dynamics are additionally regulated by the interaction between distinct posttranslational modifications, together with ubiquitination and phosphorylation. Understanding the precise mechanisms of palmitoylation could reveal novel potential therapeutic targets for a lot of human illnesses.

Monoclonal Antibody to Histatin 1 (HTN1)

MAF487Hu21 100ul
EUR 259

Histatin 1 (HTN1) Monoclonal Antibody (Human)

4-MAF487Hu21
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1)

Histatin 1 (HTN1) Monoclonal Antibody (Human), PE

4-MAF487Hu21-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with PE.

Histatin 1 (HTN1) Monoclonal Antibody (Human), APC

4-MAF487Hu21-APC
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  • 100ul
  • 10ml
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  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with APC.

Histatin 1 (HTN1) Monoclonal Antibody (Human), Cy3

4-MAF487Hu21-Cy3
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with Cy3.

Histatin 1 (HTN1) Monoclonal Antibody (Human), HRP

4-MAF487Hu21-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with HRP.

Histatin 1 (HTN1) Monoclonal Antibody (Human), FITC

4-MAF487Hu21-FITC
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  • 100ul
  • 10ml
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  • 200ul
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Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with FITC.

Histatin 1 (HTN1) Monoclonal Antibody (Human), Biotinylated

4-MAF487Hu21-Biotin
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  • 100ul
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  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with Biotin.

Histatin 1 (HTN1) Monoclonal Antibody (Human), APC-Cy7

4-MAF487Hu21-APC-Cy7
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  • 100ul
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  • 200ul
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Description: A Mouse monoclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with APC-Cy7.

Biotin-Linked Monoclonal Antibody to Histatin 1 (HTN1)

LAF487Hu72 252 ul
EUR 285

Histatin 1 (HTN1) Antibody

20-abx100580
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Histatin 1 (HTN1) Antibody

20-abx100581
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 5 ug

Histatin 1 (HTN1) Antibody

abx100580-100l 100 µl
EUR 275

Histatin 1 (HTN1) Antibody

abx100580-1ml 1 ml
EUR 750

Histatin 1 (HTN1) Antibody

abx100580-200l 200 µl
EUR 337.5

Histatin 1 (HTN1) Antibody

abx100581-100l 100 µl
EUR 275

Histatin 1 (HTN1) Antibody

abx100581-1ml 1 ml
EUR 787.5

Histatin 1 (HTN1) Antibody

abx100581-200l 200 µl
EUR 350

Histatin 1 (HTN1) Antibody Pair

20-abx370400
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  • 10 × 96 tests
  • 5 × 96 tests

Histatin 1 (HTN1) Antibody (FITC)

20-abx273578
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Histatin 1 (HTN1) Antibody (FITC)

abx273578-10mg 10 mg
EUR 437.5

Histatin 1 (HTN1) Antibody (FITC)

abx273578-50mg 50 mg
EUR 1050

Histatin 1 (HTN1) Antibody Pair

abx370400-100g 100 µg
EUR 1337.5

Histatin 1 (HTN1) Antibody (Biotin)

20-abx274562
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Histatin 1 (HTN1) Antibody (Biotin)

20-abx272379
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Histatin 1 (HTN1) Antibody (Biotin)

abx274562-96tests 96 tests
EUR 300

Histatin 1 (HTN1) Antibody (Biotin)

abx272379-1ml 1 ml
EUR 825

Histatin 1 (HTN1) Antibody (Biotin)

abx272379-200l 200 µl
EUR 362.5

Histatin 1 (HTN1) Polyclonal Antibody

CAU22480-100ul 100ul
EUR 235.2

Histatin 1 (HTN1) Polyclonal Antibody

CAU22480-200ul 200ul
EUR 294

Polyclonal Antibody to Histatin 1 (HTN1)

PAF487Hu01 100ul
EUR 245

Histatin 1 (HTN1) Polyclonal Antibody (Human)

4-PAF487Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1)

HTN1 (untagged)-Human histatin 1 (HTN1)

SC303131 10 µg Ask for price

HTN1 (untagged)-Human histatin 1 (HTN1)

SC321103 10 µg Ask for price

Histatin 1 (HTN1) Polyclonal Antibody (Human), PE

4-PAF487Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with PE.

Histatin 1 (HTN1) Polyclonal Antibody (Human), APC

4-PAF487Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with APC.

Histatin 1 (HTN1) Polyclonal Antibody (Human), Cy3

4-PAF487Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with Cy3.

Histatin 1 (HTN1) Polyclonal Antibody (Human), HRP

4-PAF487Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with HRP.

Histatin 1 (HTN1) Polyclonal Antibody (Human), FITC

4-PAF487Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with FITC.

Recombinant Histatin 1 (HTN1)

RPU41917-100ug 100ug
EUR 616

Recombinant Histatin 1 (HTN1)

RPU41917-1mg 1mg
EUR 2730

Recombinant Histatin 1 (HTN1)

RPU41917-50ug 50ug
EUR 495

Recombinant Histatin 1 (HTN1)

RPF487Hu01 10ug
EUR 200

Recombinant Histatin 1 (HTN1)

4-RPF487Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Histatin 1 expressed in: E.coli

HTN1 (GFP-tagged) - Human histatin 1 (HTN1)

RG204708 10 µg Ask for price

Histatin 1 (HTN1) Polyclonal Antibody (Human), Biotinylated

4-PAF487Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with Biotin.

Histatin 1 (HTN1) Polyclonal Antibody (Human), APC-Cy7

4-PAF487Hu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Histatin 1 (HTN1). This antibody is labeled with APC-Cy7.

HTN1 (Myc-DDK-tagged)-Human histatin 1 (HTN1)

RC204708 10 µg Ask for price

Human Histatin 1 (HTN1) Protein

20-abx067111
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Histatin 1 (HTN1) Protein

abx067111-100g 100 µg
EUR 437.5

Human Histatin 1 (HTN1) Protein

abx067111-200g 200 µg
EUR 637.5

Human Histatin 1 (HTN1) Protein

abx067111-50g 50 µg
EUR 237.5

ELISA Kit for Histatin 1 (HTN1)

SEF487Hu 96Т
EUR 700

Human Histatin 1 (HTN1) CLIA Kit

20-abx494917
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Histatin 1 (HTN1) ELISA Kit

DLR-HTN1-Hu 96T
EUR 463
Description: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

DLR-HTN1-Hu-48T 48T
EUR 620.4
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Histatin 1 (HTN1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

DLR-HTN1-Hu-96T 96T
EUR 807.6
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Histatin 1 (HTN1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

EKN45912-48T 48T
EUR 378.7

Human Histatin 1 (HTN1) ELISA Kit

EKN45912-5x96T 5x96T
EUR 2569.75

Human Histatin 1 (HTN1) ELISA Kit

EKN45912-96T 96T
EUR 541

Human Histatin 1 (HTN1) ELISA Kit

EKL54382-5x96T 5x96T
EUR 3612.38

Human Histatin 1 (HTN1) ELISA Kit

EKL54382-96T 96T
EUR 760.5

Human Histatin 1 (HTN1) ELISA Kit

EKL57978-5x96T 5x96T
EUR 3793.35

Human Histatin 1 (HTN1) ELISA Kit

EKL57978-96T 96T
EUR 798.6

Human Histatin 1 (HTN1) ELISA Kit

EKU04801-48T 48T
EUR 555.66

Human Histatin 1 (HTN1) ELISA Kit

EKU04801-5x96T 5x96T
EUR 3770.55

Human Histatin 1 (HTN1) ELISA Kit

EKU04801-96T 96T
EUR 793.8

Human Histatin- 1, HTN1 ELISA KIT

ELI-27121h 96 Tests
EUR 988.8

Human Histatin 1 (HTN1) ELISA Kit

DL-HTN1-Hu 96T
EUR 441
Description: tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

EK14595 96Т
EUR 768

Human Histatin 1 (HTN1) ELISA Kit

abx571790-96tests 96 tests
EUR 990

Human Histatin 1 (HTN1) ELISA Kit

20-abx151813
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Histatin 1 (HTN1) ELISA Kit

RDR-HTN1-Hu-48T 48T
EUR 475.34
Description: tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

RDR-HTN1-Hu-48Tests 48 Tests
EUR 652.8

Human Histatin 1 (HTN1) ELISA Kit

RDR-HTN1-Hu-96T 96T
EUR 679.04
Description: tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

RDR-HTN1-Hu-96Tests 96 Tests
EUR 907.2

Human Histatin 1 (HTN1) ELISA Kit

RD-HTN1-Hu-48T 48T
EUR 452.7
Description: tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

RD-HTN1-Hu-48Tests 48 Tests
EUR 625.2

Human Histatin 1 (HTN1) ELISA Kit

RD-HTN1-Hu-96T 96T
EUR 646.7
Description: tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

RD-HTN1-Hu-96Tests 96 Tests
EUR 867.6

Human Histatin 1(HTN1)ELISA Kit

QY-E03522 96T
EUR 448.8

Human Histatin 1 (HTN1) ELISA Kit

SEF487Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Histatin 1 (HTN1) in saliva, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

SEF487Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Histatin 1 (HTN1) in saliva, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

SEF487Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Histatin 1 (HTN1) in saliva, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

SEF487Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Histatin 1 (HTN1) in saliva, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Histatin 1 (HTN1) ELISA Kit

4-SEF487Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Histatin 1 (HTN1) in samples from saliva, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Histatin-1(HTN1) Elisa Kit

EK712698 96 Wells
EUR 0.28

Human Histatin-1(HTN1) ELISA kit

CSB-EL010878HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Histatin-1 (HTN1) in samples from serum, plasma, tissue homogenates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Histatin-1(HTN1) ELISA kit

1-CSB-EL010878HU
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Histatin-1(HTN1) in samples from serum, plasma, tissue homogenates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Histatin-1 (HTN1) ELISA Kit

RK04243 96T
EUR 280

Human Histatin-1, HTN1 GENLISA ELISA

KBH5406 1 x 96 wells
EUR 286

Human HTN1 / Histatin-1 ELISA Kit

E15611h 96T
EUR 736

Human HTN1(Histatin 1) ELISA Kit

ELK4651-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HTN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HTN1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human HTN1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human HTN1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human HTN1(Histatin 1) ELISA Kit

ELK4651-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human HTN1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human HTN1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human HTN1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human HTN1 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Histatin 1 ELISA Kit (HTN1)

RK01611 96 Tests
EUR 687.6

Histatin 1 (HTN1) Magnetic Luminex Assay Kit

LKU604563-96T 96T
EUR 966

ELISA kit for Human HTN1 (Histatin 1)

ELK4651 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Histatin 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Histatin 3 (HTN3) Antibody

20-abx172820
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  • 1 mg
  • 200 ug

Histatin 3 (HTN3) Antibody

20-abx176851
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  • 1 mg
  • 200 ug

Histatin 3 (HTN3) Antibody

abx176851-1096tests 10 × 96 tests Ask for price

Histatin 3 (HTN3) Antibody

abx176851-596tests 5 × 96 tests Ask for price

Histatin 3 (HTN3) Antibody

abx176851-96tests 96 tests
EUR 750

Histatin 3 (HTN3) Antibody

abx172820-1ml 1 ml
EUR 787.5

Histatin-3 (HTN3) Antibody

abx343557-100l 100 µl
EUR 350

Histatin-3 (HTN3) Antibody

abx343557-50l 50 µl
EUR 250

Lenti ORF particles, HTN1 (mGFP-tagged) - Human histatin 1 (HTN1), 200ul, >10^7 TU/mL

RC204708L4V 200 µl Ask for price

Histatin-3 (HTN3) Antibody (HRP)

abx343558-100l 100 µl
EUR 350

Histatin-3 (HTN3) Antibody (HRP)

abx343558-50l 50 µl
EUR 250

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