Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity

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Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity

Though the respiratory tract is the first web site of SARS-CoV-2 an infection and the following immunopathology, respiratory immune responses are understudied and urgently wanted to know mechanisms underlying COVID-19 illness pathogenesis. We collected paired longitudinal blood and respiratory tract samples (endotracheal aspirate, sputum or pleural fluid) from hospitalized COVID-19 sufferers and non-COVID-19 controls. SARS-CoV-2-specific […]