Mammalian Cell-Free System Recapitulates the Early Events of Post-Fertilization Sperm Mitophagy

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Mammalian Cell-Free System Recapitulates the Early Occasions of Submit-Fertilization Sperm Mitophagy

Propagation of paternal sperm-contributed mitochondrial genes, leading to heteroplasmy, is seldom noticed in mammals attributable to post-fertilization degradation of sperm mitochondria, known as sperm mitophagy. Entire organelle sperm mitochondrion degradation is considered mediated by the interaction between the ubiquitin-proteasome system (UPS) and the autophagic pathway. Each porcine and primate post-fertilization sperm mitophagy depend on the ubiquitin-binding […]