Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia

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Hydrolysis of a second Asp-Pro site at the N-terminus of NOTCH3 in inherited vascular dementia

Cerebrovascular pathology on the biochemical stage has been knowledgeable by the examine of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a vascular dysfunction brought on by NOTCH3 mutations. Earlier work in CADASIL described N-terminal proteolysis of NOTCH3 generated by particular non-enzymatic cleavage of the primary Asp-Professional sequence of the protein. Right here, we investigated whether or […]