Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells

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Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells

Airway and intestinal epithelial permeability obstacles are essential in epithelial homeostasis. Excessive mobility group field 1 (HMGB1), elevated by numerous stimuli, is concerned within the induction of airway irritation, in addition to the pathogenesis of inflammatory bowel illness. HMGB1 enhances epithelial hyperpermeability. Two-and-a-half dimensional (2.5D) tradition assays are experimentally handy and induce cells to kind […]